顾万君

从2000年开始一直从事生物信息学、计算生物学、疾病基因组和转录组研究、疾病诊断外周血标志物等研究工作。在国内外核心刊物上发表研究论文四十余篇,其中SCI收录近40篇,包括《Molecular Biology and Evolution》、《PLoS Computational Biology》、《RNA》等期刊第一作者和通讯作者论文。论文SCI总引用近2000次。作为项目负责人完成两项国家自然科学基金面上项目和科技部863项目课题一项,目前在研一项国家自然科学基金面上项目,参与一项科技部973项目课题。任SCI期刊《Evolutionary Bioinformatics》和国内计算生物学期刊《Hans Journal of Computational Biology》编委。


 所发表论文:
* 通讯作者;#共同第一作者
Qian Z, Lv J, Kelly GT, Wang H, Zhang X, Gu W, Yin X, Wang T, Zhou T. 2016. Expression of nuclear factor, erythroid 2-like 2-mediated genes differentiates tuberculosis. Tuberculosis 99: 56-62.
Luo Y, Huang C, Ye J, Fang W, Gu W, Chen Z, Li H, Wang XJ, Jin D. 2016. Genome Sequence and Analysis of Peptoclostridium difficile Strain ZJCDC-S82. Evolutionary bioinformatics online 12: 41.
Wang R, Gurguis CI, Gu W, Ko EA, Lim I, Bang H, Zhou T, Ko J-H. 2015. Ion channel gene expression predicts survival in glioma patients. Scientific Reports 5: 11593.
Gu W*, Gurguis CI, Zhou J, Zhu Y, Ko E-A, Ko J-H, Wang T, Zhou T. 2015. Functional and structural consequence of rare exonic single nucleotide polymorphisms: one story, two tales. Genome biology and evolution 7: 2929-2940.
Li C, Zhang Y, Li J, Kong L, Hu H, Pan H, Xu L, Deng Y, Li Q, Jin L…Gu W…(52 authors) 2014. Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment. GigaScience 3: 1-15.
Ko J-H#, Gu W#, Lim I, Zhou T, Bang H. 2014. Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. PLoS ONE 9: e110094.
Ko J-H, Gu W, Lim I, Bang H, Ko EA, Zhou T. 2014. Ion channel gene expression in lung adenocarcinoma: potential role in prognosis and diagnosis. PLoS ONE 9: e86569.
Gu W*, Xu Y, Xie X, Wang T, Ko J-H, Zhou T. 2014. The role of RNA structure at 5′ untranslated region in microRNA-mediated gene regulation. RNA (New York, NY) 20: 1369-1375.
Gu W*, Li M, Xu Y, Wang T, Ko J-H, Zhou T. 2014. The impact of RNA structure on coding sequence evolution in both bacteria and eukaryotes. BMC Evolutionary Biology 14: 87.
Ko J-H, Ko EA, Gu W, Lim I, Bang H, Zhou T. 2013. Expression profiling of ion channel genes predicts clinical outcome in breast cancer. Molecular Cancer 12: 106.
Gu W*, Wang X, Zhai C, Zhou T, Xie X. 2013. Biological basis of miRNA action when their targets are located in human protein coding region. PLoS ONE 8: e63403.
Castoe TA, De Koning AJ, Hall KT, Card DC, Schield DR, Fujita MK, Ruggiero RP, Degner JF, Daza JM, Gu W. … (32 authors) 2013. The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. Proceedings of the National Academy of Sciences 110: 20645-20650.
Zhou T, Ko EA, Gu W, Lim I, Bang H, Ko J-H. 2012. Non-silent story on synonymous sites in voltage-gated ion channel genes. PLoS ONE 7: e48541.
Guo L, Li H, Lu J, Yang Q, Ge Q, Gu W, Bai Y, Lu Z. 2012. Tracking miRNA precursor metabolic products and processing sites through completely analyzing high-throughput sequencing data. Molecular Biology Reports 39: 2031-2038.
Gu W*, Zhai C, Wang X, Xie X, Parinandi G, Zhou T. 2012. Translation Efficiency in Upstream Region of microRNA Targets in Arabidopsis thaliana. Evolutionary Bioinformatics Online 8: 565.
Gu W*, Wang X, Zhai C, Xie X, Zhou T. 2012. Selection on synonymous sites for increased accessibility around miRNA binding sites in plants. Molecular Biology and Evolution 29: 3037-3044.
de Koning AJ, Gu W, Castoe TA, Pollock DD. 2012. Phylogenetics, likelihood, evolution and complexity. Bioinformatics 28: 2989-2990.
Guo L, Yang Q, Lu J, Li H, Ge Q, Gu W, Bai Y, Lu Z. 2011. A comprehensive survey of miRNA repertoire and 3′ addition events in the placentas of patients with pre-eclampsia from high-throughput sequencing. PLoS ONE 6: e21072.
Guo L, Liang T, Gu W, Xu Y, Bai Y, Lu Z. 2011. Cross-mapping events in miRNAs reveal potential miRNA-mimics and evolutionary implications. PLoS ONE 6: e20517.
de Koning AJ, Gu W, Castoe TA, Batzer MA, Pollock DD. 2011. Repetitive elements may comprise over two-thirds of the human genome. PLoS Genet 7: e1002384.
Castoe TA, Hall KT, Mboulas MLG, Gu W, de Koning AJ, Fox SE, Poole AW, Vemulapalli V, Daza JM, Mockler T. 2011. Discovery of highly divergent repeat landscapes in snake genomes using high-throughput sequencing. Genome biology and evolution 3: 641-653.
Castoe TA, de Koning AJ, Hall KT, Yokoyama KD, Gu W, Smith EN, Feschotte C, Uetz P, Ray DA, Dobry J. 2011. Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes. Genome Biol 12: 406.
Zhou T, Gu W, Wilke CO. 2010. Detecting positive and purifying selection at synonymous sites in yeast and worm. Molecular Biology and Evolution 27: 1912-1922.
Warren WC, Clayton DF, Ellegren H, Arnold AP, Hillier LW, Künstner A, Searle S, White S, Vilella AJ, Fairley S…Gu W…(61 authors). 2010. The genome of a songbird. Nature 464: 757-762.
Li R, Fan W, Tian G, Zhu H, He L, Cai J, Huang Q, Cai Q, Li B, Bai Y. …Gu W, … (58 authors) 2010. The sequence and de novo assembly of the giant panda genome. Nature 463: 311-317.
Gu W#, Zhou T#, Wilke CO. 2010. A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes. PLoS Comput Biol 6: e1000664.
de Koning AJ, Gu W, Pollock DD. 2010. Rapid likelihood analysis on large phylogenies using partial sampling of substitution histories. Molecular biology and evolution 27: 249-265.
Castoe TA, Poole AW, Gu W, Jason de Koning A, Daza JM, Smith EN, Pollock DD. 2010. Rapid identification of thousands of copperhead snake (Agkistrodon contortrix) microsatellite loci from modest amounts of 454 shotgun genome sequence. Molecular Ecology Resources 10: 341-347.
Castoe T, Gu W, De Koning A, Daza J, Jiang Z, Parkinson C, Pollock D. 2010. Dynamic nucleotide mutation gradients and control region usage in squamate reptile mitochondrial genomes. Cytogenetic and genome research 127: 112-127.
Tonsmann G, Pollock DD, Gu W, Castoe TA. 2009. Identifying DNA Strands Using a Kernel of Classified Sequences. In Computer Science and Information Engineering, 2009 WRI World Congress on, Vol 3, pp. 703-707. IEEE.
Castoe TA, de Koning AJ, Kim H-M, Gu W, Noonan BP, Naylor G, Jiang ZJ, Parkinson CL, Pollock DD. 2009. Evidence for an ancient adaptive episode of convergent molecular evolution. Proceedings of the National Academy of Sciences 106: 8986-8991.
Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ. 2008. Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus. Journal of molecular biology 378: 71-86.
Gu W, Castoe TA, Hedges DJ, Batzer MA, Pollock DD. 2008. Identification of repeat structure in large genomes using repeat probability clouds. Analytical biochemistry 380: 77-83.
Castoe TA, Jiang ZJ, Gu W, Wang ZO, Pollock DD. 2008. Adaptive evolution and functional redesign of core metabolic proteins in snakes. PLoS One 3: e2201.
Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A. ... Gu W… (62 authors) 2007. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447: 167-177.
Gu W#, Ray DA#, Walker JA, Barnes EW, Gentles AJ, Samollow PB, Jurka J, Batzer MA, Pollock DD. 2007. SINEs, evolution and genome structure in the opossum. Gene 396: 46-58.
Gentles AJ, Wakefield MJ, Kohany O, Gu W, Batzer MA, Pollock DD, Jurka J. 2007. Evolutionary dynamics of transposable elements in the short-tailed opossum Monodelphis domestica. Genome research 17: 992-1004.
Zhou T, Gu W, Ma J, Sun X, Lu Z. 2005. Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses. Biosystems 81: 77-86
Gu W, Zhou T, Ma J, Sun X, Lu Z. 2004. Analysis of synonymous codon usage in SARS Coronavirus and other viruses in the Nidovirales. Virus research 101: 155-161.
Gu W, Zhou T, Ma J, Sun X, Lu Z. 2004 The relationship between synonymous codon usage and protein structure in Escherichia coli and Homo sapiens. Biosystems 73: 89-97
Gu W, Zhou T, Ma J, Sun X, Lu Z. 2003. Folding type specific secondary structure propensities of synonymous codons. NanoBioscience, IEEE Transactions on 2: 150-157.
Ma J, Zhou T, Gu W, Sun X, Lu Z. 2002. Cluster analysis of the codon use frequency of MHC genes from different species. Biosystems 65: 199-207.