陈磊

现为第二军医大学附属东方肝胆外科医院副研究员,课题组组长;获国家自然科学基金委优秀青年科学基金。美国癌症学会会员(active member)。中国医师协会临床精准医疗专业委员会常务委员兼副总干事长,中华预防医学会微生态学分会委员,上海市遗传学会第十届理事会理事,中华医学会消化病学分会生物样本库与转化医学协作组成员,国家自然科学基金委面上项目和青年基金项目评审专家,浙江省自然科学基金同行评议专家。

主要从事肝癌早期预警标志物以及肝脏疾病信号转导机制方面的研究。在Nature Cell Biology,J.E.M, Gastroenterology, Gut, Hepatology, Cancer Research, Journal of Hepatology, Journal of Virology, Molecular Cancer, FEBS Journal, J.B.C等国际重要学术期刊发表署名SCI论文44篇,总引用次数1307次,H-index:19。发表第一作者(含并列)和通讯作者(含并列)SCI论文15篇,总影响因子133.06,其中影响因子大于10分论文7篇(近五年发表6篇),单篇论文他引最高95次。
获国家自然科学基金委优秀青年科学基金。主持国家自然科学基金面上项目2项,国家基金委重大研究计划培育项目1项,国家卫生部国家科学技术部十二五传染病重大专项子课题1项。主持上海市青年科技启明星计划,上海市卫计委新优青计划,上海市教委教育发展基金会晨光计划,第二军医大学优秀青年学者,上海高校选拔培养优秀青年教师科研专项基金, 总后勤部优秀青年科技人才扶持对象。
2015年获第八届吴孟超医学青年基金奖,2014年获第七届上海市青年科技英才,2014年获明治生命科学奖(二等奖),2008年获得上海市医学科技一等奖(第三完成人),获上海市优秀博士学位论文,获军队三等功一次(2012),校学习成才标兵个人。2007年获全军生化与分子生物学大会组委会授予的“青年优秀论文”称号。2008年作为百名内地年轻科学家之一受邀参加沪港国际肝病会议并作报告。2009年受邀参加在意大利米兰举办的第三届国际肝癌年会。
获国家发明专利授权两项,申报国家发明专利五项。
参与编写《生物化学--基础理论与临床》(科学出版社)和《信号转导基本理论与常用技术》(上海科技教育出版社)两部专著。
 
近年主要发表论文(*:第一/并列第一作者和并列通讯作者文章):
  1. Yingcheng Yang, Ximeng Lin, Xinyuan Lu, Guijuan Luo,Tao Zeng, Jing Tang, Feng Jiang, Liang Li, Xiuliang Cui, Wentao Huang,Guojun Hou, Xin Chen, Qing Ouyang, Shanhua Tang,Huanlin Sun,Luonan Chen,Mengchao Wu,Frank J. Gonzalez,Wenming Cong,Lei Chen*, Hongyang Wang*. Interferon-MicroRNA Signaling Drives Liver Precancerous Lesion Formation and Hepatocarcinogenesis. Gut, 2016 Feb 9. pii: gutjnl-2015-310318. doi: 10.1136/gutjnl-2015-310318. [Epub ahead of print](IF=14.921)
  2. Jing Tang*, Liang Li*, Wentao Huang*, Chengjun Suib, Yingcheng Yang, Ximeng Lin, Guojun Hou, Xin Chen, Jing Fu, Shengxian Yuan, Shao Li, Wen Wen, Shanhua Tang, Dan Cao, MengchaoWu, Lei Chen* and Hongyang Wang*.MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. Cancer Letters, 2016,373(2):234-240. (IF=5.992)
  3. Feng Jiang*, Lei Chen*, Ying-Cheng Yang*, Xian-Ming wang, Ruo-Yu Wang, Liang Li, Wen Wen, Yan-Xin Chang, Cai-Yang Chen, Jing Tang, Gao-Mi-Yang Liu, Wen-Tao Huang, Lin Xu, and Hong-Yang Wang. CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signalin. Cancer Research, 2015 Apr 1;75(7):1470-81. (IF=8.556)
  4. Liang Li, Jing Tang, Wen Yang, Haiyang Chen, Miyang Liu Gao, Ruoyu Wang, Yexiong Tan, Jianling Fan, Yanxin Chang, Jing Fu, Feng Jiang, Caiyang Chen, Yingcheng Yang, Dingming Wu, Ruiying Zheng,  Hengyu Li, Baohua Zhang, Mengchao Wu, Michael.Q Zhang, Lei Chen* and Hongyang Wang*. Epigenetic Modification of miR-429 in Hepatocellular Carcinoma Manipulates EpCAM+ Liver Tumor-Initiating Cells Properties via Targeting RBBP4/E2F1/Oct4 Axis. Gut, 2015;64:1156-167. (IF=14.921) 
  5. Jing Tang, Liang Li, Wentao Huang, Chengjun Suib, Yingcheng Yang, Ximeng Lin, Guojun Hou, Xin Chen, Jing Fu, Shengxian Yuan, Shao Li, Wen Wen, Shanhua Tang, Dan Cao, MengchaoWu, Lei Chen* and Hongyang Wang*.MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. Cancer Letters, 2015,364(1):33-43. (IF=5.992)
  6. Qian-qian TU, Rui-ying ZHENG, Juan LI, Liang HU, Yan-xin CHANG, Liang LI, Min-hong LI, Ruo-yu WANG, Dan-dan HUANG, Meng-chao WU, He-ping HU*, Chen Lei*(陈磊,通讯作者)and Hong-yang Wang. Palmitic acid induces autophagy in hepatocytes via JNK2 activation. Acta Pharmacologica Sinica, 2014 Apr; 35(4): 504-512. (IF=2.124)
  7. RuoYu Wang*, Lei Chen*, HaiYang Chen*, Liang Hu, Liang Li, HanYong Sun, Feng Jiang, GaoMinyang Liu, Jing Tang, CaiYang Chen, YingCheng Yang, YanXin Chang, Hui Liu, Jin Zhang, Yuan Yang, MengChao Wu, Feng Shen, WeiPing Zhou, and HongYang Wang. MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated with Aggressive Hepatocellular Carcinomas in Patients. Gastroenterology, 2013 Dec;145(6):1436-48. (IF=18.187)
  8. Yanxin Chang, Chen Liu, Jiahe Yang, Gaomiyang Liu, Feiling Feng,Jing Tang, Liang Hu, Liang Li, Feng Jiang, Caiyang Chen, Ruoyu Wang, Yingcheng Yang, Xiaoqing Jiang, Mengchao Wu, Lei Chen* and Hongyang Wang*. MiR-20a Triggers Metastasis of Gallbladder Carcinoma. Journal of Hepatology, 2013 Sep;59(3):518-27. (IF=10.590)
  9. Li Liang*, Chen Lei*, Hu Liang, Liu Yuan, Sun Han-Yong, Tang Jing, Hou Yu-Jie, Chang Yan-Xin, Tu Qian-Qian, Feng Gen-Sheng, Shen Feng, Wu Meng-Chao, Wang Hong-Yang. Nuclear Factor High-Mobility Group Box1 Mediating the Activation of Toll-Like Receptor 4 Signaling in Hepatocytes in the Early Stage of Nonalcoholic Fatty Liver Disease in Mice. Hepatology, 2011,54(5), pp 1620-1630. (IF=11.711)
  10. Chen Lei*, Yan He-Xin, Yang Wen, Hu Liang, Yu Le-Xin, Liu Qiong, Li Liang, Huang Dan-Dan, Ding Jin, Shen Feng, Zhou Wei-Ping, Wu Meng-Chao, Wang Hong-Yang. The role of microRNA expression pattern in human intrahepatic cholangiocarcinoma. Journal of Hepatology, 2009,50(2), pp 358-369. (IF=10.590)
  11. Sun HanYong*, Chen Lei*, Zhou WeiPing, Hu Liang, Li Liang, Tu QianQian, Chang YanXin, Liu Qu, Sun XueJun, Wu MengChao, Wang HongYang. The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011,54(3), pp 471-480. (IF=10.590)
  12. Liang Hu*, lei Chen*, Liang Li, HanYong Sun, GuangZhen Yang, YanXin Chang, QianQian Tu, MengChao Wu,HongYang Wang,Hepatitis B Virus X Protein Enhances Cisplatin-Induced Hepatotoxicity via a Mechanism Involving Degradation of Mcl-1,Journal of Virology, 2011,1(1), pp 3214-3218. (IF=4.606) 
  13. Hu Liang*, Chen Lei*, Yang GuangZhen, Li Liang, Sun HanYong, Chang YanXin, Tu QianQian, Wu MengChao, Wang HongYang. HBx Sensitizes Cells to Oxidative Stress-induced Apoptosis by Accelerating the Loss of Mcl-1 Protein via Caspase-3 Cascade. Molecular Cancer, 2011,10卷, pp 43-50. (IF=5.888) 
  14. Lei Chen*, He-Xin Yan, Jing Chen, Wen Yang, Qiong Liu, Bo Zhai, Hui-Fang Cao, Shu-Qin Liu, Meng-Chao Wu, Hong-Yang Wang ,Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1. Endocrinology, 2007,148(5), pp 2168-2180. (IF=4.159) 
  15. Chang Yanxin*, Chen Lei*, Liu Yuan, Hu Liang, Li Liang, Tu Qianqian, Wang Ruoyu, Wu Mengchao,Yang Jiahe, Wang Hongyang. Inhibition of autophagy may suppress the development of hepatoblastoma. The Febs Journal, 2011,278(24), pp 4811-4823.(IF=4.237) 
  16. Hanane Lanaya, Anuradha Natarajan, Karin Komposch, Liang Li, Nicole Amberg, Lei Chen,Stefanie K.Wculek, Martina Hammer, Rainer Zenz,Markus Peck-Radosavljevic, Wolfgang Sieghart, Michael Trauner, HongyangWang andMaria Sibilia. EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation. Nature Cell Biology, 2014,16(10),972-981. (IF=)
  17. Kong Xiao-Ni, Yan He-Xin, Chen Lei, Dong Li-Wei, Yang Wen, Liu Qiong, Yu Le-Xing, Huang Dan-Dan, Liu Shu-Qin, Liu Hui, Wu Meng-Chao, Wang Hong-Yang. LPS-induced down-regulation of signalregulatory protein alpha contributes to innate immune activation in macrophages. Journal of Experimental Medicine, 2007,204(11), pp 2719-2731. (IF=11.240) 
  18. Yang Wen, Yan He-Xin, Chen Lei, Liu Qiong, He Ya-Qin, Yu Le-Xing, Zhang Shu-Hui, Huang Dan-Dan, Tang Liang, Kong Xiao-Ni, Chen Chao, Liu Shu-Qin, Wu Meng-Chao,Wang Hongyang. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Research, 2008,68(11), pp4287-4295. (IF=8.556) 
  19. Wang Di, Wang Fei, Tan Yexiong, Dong Liwei, Chen Lei, Zhu Weiliang, Wang Hongyang. Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay. Bioorganic and Medicinal Chemistry Letters, 2012,22(1), pp 168-171 
  20. Wen Wen, Ding Jin, Sun Wen, Wu Kun, Ning Beifang, Gong Wenfeng, He Guoping, Huang Shanna, Ding Xinyu, Yin Peipei, Chen Lei, Liu Qiong, Xie Weifen, Wang Hongyang. Suppression of Cyclin D1 by Hypoxia-Inducible Factor-1 via Direct Mechanism Inhibits the Proliferation and 5-Fluorouracil-Induced Apoptosis of A549 Cells. Cancer Research, 2010,70(5), pp 2010-2019. (IF=8.556) 
  21. Liu Qiong, Zhai Bo, Yang Wen, Yu Le-Xing, Dong Wei, He Ya-Qin, Chen Lei, Tang Liang, Lin Yan, Huang Dan-Dan, Wu Hong-Ping, Wu Meng-Chao, Yan He-Xin, Wang Hong-Yang. Abrogation of Local CancerRecurrence After Radiofrequency Ablation by Dendritic Cell-based Hyperthermic Tumor Vaccine. Molecular Therapy, 2009,17(12), pp 2049-2057
  22. Zhai Bo, Yan He-Xin, Liu Shu-Qin, Chen Lei, Wu Meng-Chao, Wang Hong-Yang. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. World Journal of Gastroenterology, 2008,14(37), pp5665-5673 
  23. Zhai Bo, Yan He-Xin, Liu Shu-Qin, Chen Lei, Wu Meng-Chao, Wang Hong-Yang. Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters. World Journal of Gastroenterology, 2008,14(23), pp 3739-3744 
  24. Dong Li-Wei, Kong Xiao-Ni, Yan He-Xin, Yu Le-Xing, Chen Lei, Yang Wen, Liu Qiong, Huang Dan-Dan, Wu Meng-Chao, Wang Hong-Yang. Signal regulatory protein alpha negatively regulates both TLR3 andcytoplasmic pathways in type I interferon induction. Molecular Immunology, 2008,45(11), pp 3025-3035